First FDA Approved Generic Lidocaine 1.8% Patch

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Man holding his hand over a pain relief patch on the back of his neck

On March 26, 2025, the U.S. Food and Drug Administration (FDA) approved a generic version of ZTlido™. The first-of-its-kind generic lidocaine 1.8% patch is produced by Aveva Drug Delivery systems (a DifGen company), a leader in transdermal drug delivery systems based out of Miramar, Florida. The generic lidocaine patch:

  • Provides patients suffering from localized nerve pain a more affordable, effective, and accessible treatment option.
  • Uses a unique patch design that is bioequivalent to other lidocaine patches, such as Lidoderm® (lidocaine) 5% patch, with an adhesive that provides more consistent skin contact.

Brand name ZTlido, a non-opioid topical treatment for post-herpetic neuralgia (PHN), is manufactured by Scilex Pharmacueticals. ZTlido is a non-hydrogel patch that delivers a local dose of lidocaine, offering relief directly at the site of pain.

MyMatrixx Actions

While newly approved, the generic lidocaine 1.8% patch has not launched on the market. The MyMatrixx clinical team will continue to monitor for updates on the generic patch pricing.